Mechanism of Ribonuclease A Endocytosis: Analogies to Cell-Penetrating Peptides
نویسندگان
چکیده
منابع مشابه
Mechanism of ribonuclease A endocytosis: analogies to cell-penetrating peptides.
Pancreatic-type ribonucleases can exert toxic activity by catalyzing the degradation of cellular RNA. Their ability to enter cells is essential for their cytotoxicity. Here, we determine the mechanism by which bovine pancreatic ribonuclease (RNase A) enters human cells. Inhibiting clathrin-dependent endocytosis with dynasore or chlorpromazine decreases RNase A-uptake by ~70%. Limited colocaliza...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2011
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi2009079